From genes to cells to disease
Welcome to the laboratory of Stephen B. Montgomery at Stanford University School of Medicine. Our lab focuses on understanding the mechanisms by which genetic variation influences cellular mechanisms and, ultimately, human traits. We utilize high throughput next generation sequencing to interrogate genomes and genome function in combination with novel bioinformatics and statistical genetics tools.
We envision a future where when one goes to the clinic, not only can we access the genome, but we can access layers of cellular phenotypes which will allow us to make unprecedented predictions regarding disease risk.
April 18th, 2012: Kim Kukurba awarded a Dept of Defense Graduate Research Fellowship
April 16th, 2012: Mauro Pala joins the lab
April 2th, 2012: Mark Piercy joins the lab
Mar 30th, 2012: Kim Kukurba awarded an NSF Graduate Research Fellowship
Feb 8th, 2012: Our work gets featured in Nature.
Jan 3rd, 2012: Dr Xin Li joins the lab
Dec 1, 2011: Profiled by Genome Technology magazine.
Sept 23rd, 2011: Dr Kevin Smith joins the lab
July 1, 2011: The lab opens its doors in the Department of Pathology. Actively seeking postdoctoral researchers and graduate students.
April 5th, 2012: Halifax, Canada Dalhousie, Department of Pathology, Seminar Series
April 20th, 2012: Stanford, California 3rd Annual Stanford Symposium for Genomics and Personalized Medicine
May 8th-12th, 2012: CSHL, NY Biology of the Genomes - Xin Li
May 30th, 2012: Liege, Belgium Capita Selecta in Complex Disease Analysis
Aug 19th-23rd, 2012: Toronto, Canada The 13th International Conference on Systems Biology
Stranger, B.E., Montgomery, S.B., Dimas, A.S., et al. Patterns of Cis Regulatory Variation in Diverse Human Populations PLoS Genetics, Apr 2012
Macarthur et al. A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes Science, Feb 2012
Paternoster et al.Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, Dec 2011
Lappalainen et al. Epistatic Selection between Coding and Regulatory Variation in Human Evolution and Disease American Journal of Human Genetics, Sept 2011
Sharp et al. DNA methylation profiles of human active and inactive X chromosomes Genome Research, Aug 2011